Prof. Dr. Benjamin Gantenbein-Ritter
Group Head - Tissue Mechanobiology (TOM)
University of Bern, Medical Faculty
Institute for Surgical Technology and Biomechanics
Phone: +41 31 631 59 26
Fax: +41 31 631 59 60
Activties and Research Interests
The Tissue & Organ Mechanobiology (TOM) Group conducts research leading towards improving the current treatment methods for degenerative disorders and traumatic injuries of the spine. The group focuses its efforts on developing a better understanding of the interaction between living tissues and biomaterials, studying the influence of mechanical and physiological stimuli on tissue repair and development, and evaluating the potential for achieving a successful biological repair to an injury or to degeneration. We employ a variety of cell, tissue and organ level models in the study of normal and compromised intervertebral disc metabolism. A major initiative in our group is the development of appropriate three-dimensional scaffolds for the repair of annular and nucleus defects. Our first concepts for disc repair strategies have been evaluated in the laboratory and have proceeded through successful pre-clinical in vivo trials.
- Chan, SC, Gantenbein-Ritter, B. 2012a; Intervertebral disc regeneration or repair with biomaterials and stem cell therapy--feasible or fiction? Swiss Med Wkly 142 w13598.
- Chan, SCW, Gantenbein-Ritter, B. 2012b; Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture. J Vis Exp 60(60): e3490.
- Chan, SC, Ferguson, SJ, Gantenbein-Ritter, B. 2011; The effects of dynamic loading on the intervertebral disc. Eur Spine J 20(11): 1796-1812.
- Chan, SC, Ferguson, SJ, Wuertz, K, et al. 2011; Biological response of the intervertebral disc to repetitive short term cyclic torsion. Spine 36(24): 2021-2030.
- Gantenbein-Ritter, B, Benneker, LM, Alini, M, et al. 2011; Differential response of human bone marrow stromal cells to either TGF-β(1) or rhGDF-5. Eur Spine J 20 962-971.
- Gantenbein-Ritter, B, Chan, SC. 2011; The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study. Eur Spine J 21 Suppl 6 819-825.
- Gantenbein-Ritter, B., Sakai, D. (2011). Biomaterials for Intervertebral Disc Regeneration. In Comprehensive Biomaterials: 161-169. Ducheyne, P., Healy, K. E., Hutmacher, D., Grainger, D. W., Kirkpatrick, C. J. (Eds.). Elsevier.
- Malonzo, C, Chan, SCW, Peroglio, M, et al. 2012 (in press); Thermo-reversible hydrogel for nucleus pulposus replacement: feasibility under static loading in a mild papain-induced disc degeneration model. J Tissue Eng Regen Med.
- Seiler, C, Gazdhar, A, Reyes, M, et al. 2012; Time-lapse microscopy and classification of 2D human mesenchymal stem cells based on cell shape picks up myogenic from osteogenic and adipogenic differentiation. J Tissue Eng Regen Med epub ahead of print
- Steiner, TH, Bürki, A, Ferguson, SJ, Gantenbein-Ritter B. 2012; Stochastic amplitude-modulated stretching of Rabbit flexor digitorum profundus tendons reduces stiffness compared to Cyclic Loading but does not affect Tenocyte Metabolism. BMC Musculoskelet Disord 13(1): 222.